Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The remaining of the top 10 were the University of Luxembourg (second), Ecole Polytechnique Federale de Lausanne (fourth), University of Geneva (fifth), ETH Zurich - Swiss Federal Institute of Technology Zurich (seventh), University of St. Gallen (eighth), National University of Singapore (ninth) and Imperial College London (10th).
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
"This is a hard one for people to understand how they're doing it, but it's an easy one for managers to pick up," Kay says. In many cases, you're disengaged, or as Kay describes it: "not being totally mentally present." Maybe you used to chime in a lot during meetings, and now you're quiet. Maybe you're not producing as much as you used to. Maybe you're not excited about a new project you've been asked to manage。
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Surveys indicate that a majority of women suffer or have suffered gender prejudice when looking for a job, because employers do not want to grant maternity leave. To avoid possible gender discrimination from employers as a result of their entitlement to maternity leave and increase their employment competitiveness, some female job seekers have reportedly chosen to get married and have their children before graduating from universities.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
'I was blown away by him,' Kushner recalls. 'The first time I interacted with him was at News Corp, when he was meeting with Murdoch, and I was looped in to provide perspective. Nick described the vision of what he was trying to accomplish. And he was providing insight to Rupert.' D'Aloisio's stage presence, coupled with the deep-pocketed credibility brought by Li, attracted a large group of benefactors to Summly, including Ashton Kutcher, Yoko Ono and Stephen Fry.
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
“We have not really assumed China will get better in the rest of the year,” said James Quincey, Coca-Cola’s chief operating officer. He said juice sales fell double digits in the second quarter in the country and Coca-Cola drinks dropped single digits.
Novel biosensing methodologies for ultrasensitive detection of viruses
The dollar value of exports from emerging market countries will rise next year for the first time since 2014, helped by higher commodity prices and modestly stronger demand, it is predicted.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Sectors: what’s in
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
来自荷兰的Anita Eerland和Rolf Zwaan，以及来自秘鲁的Tulio Guadalupe被授予心理学奖，其研究题目是《向左倚靠会让埃菲尔铁塔看上去更小一些》。
Yet the pizza is far from the first recipe to incorporate a bit of the precious metal. Earlier this year, Bj?rn DelaCruz, the owner of Filipino restaurant the Manila Social Club, in Williamsburg, New York, created the pricey Golden Cristal Ube Donut.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Emma Morano’s singular achievement in life may have been perseverance. She lived for 117 years, crediting her longevity to raw eggs and her lack of a husband. She died on April 15.
Singer Susan Boyle came undone -- literally, when her trousers popped open at a soccer match as she waved a Celtic fan above her head in Scotland. The "Britain
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Plans to open 20,000 specialist football schools in 2017, aimed at training young players and cultivating talent, are part of the government's latest plan to advance China's ability to compete on the global pitch.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
“It is exceptionally unlikely that we would be witnessing a record year of warmth, during a record-warm decade, during a several decades-long period of warmth that appears to be unrivaled for more than a thousand years, were it not for the rising levels of planet-warming gases produced by the burning of fossil fuels,” Michael E. Mann, a climate scientist at the Pennsylvania State University, said in an email.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Denmark, for instance, is 88 percent white Danish today — hardly a majority in jeopardy. But a generation ago, in 1980, it was 97 percent white. The anti-immigrant Danish People’s Party is now the second-largest party in the Danish Parliament. In Germany, where the foreign-born population shot up by approximately 75 percent between 2011 and 2015, the anti-immigrant, populist Alternative for Germany party is now drawing record support.
Antiviral drug discovery: broad-spectrum drugs from nature
“Who’s going to pay for that?” said Marc J. Luxemburg, the president of the Council of New York Cooperatives and Condominiums. “This has a real-world cost for many buildings.”
HEC Paris is second despite outperforming LBS in all rankings but the MBA. It missed out on a full house because of its participation in the executive MBA ranking as one-third of Trium, the programme delivered jointly with London School of Economics and New York’s Stern School of Business. (Schools participating in the EMBA ranking with joint programmes receive a proportionate score.)
Influenza neuraminidase: A druggable target for natural products
It is believed that the rise of South Korea's pop music industry is behind the boom, and many patients visit clinics with photos of celebrities, asking surgeons to emulate nose angle or eyes.
"A 12-year-old boy doesn't want to start spending 100,000 euros."
London Business School has topped the European table for the third year running — but continental rivals lead the European schools in the individual rankings used to compile it.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
周二，土耳其总统雷杰普?塔伊普?埃尔多安(Recep Tayyip Erdogan)对荷兰的外交声讨升级，他宣称荷兰“品德败坏”，并认为荷兰军队对二战以来欧洲最恶劣的大屠杀难辞其咎。
The role of biosensors in the detection of emerging infectious diseases
I'm going to disagree on one team you mentioned: the Kings. The West is a bit shallow again, and Sacramento is in the mix for a playoff spot. It's not likely or anything, but so long as they are in the mix, they have to pull out almost all the stops to grab it.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
"There are close to 70 French citizens or residents in France who have died in Syria and Iraq in the ranks of the terrorists," he added.
Elsewhere, Australia recently introduced reforms that have increased transparency around fund pricing, which has driven rapid growth in ETFs.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
During the summers, Good Humor ice cream trucks visit the company's campuses every other Friday during lunchtime. In the fall, cider and doughnuts are served twice a month, mid-morning.
Will Theresa May remain prime minister in 2018
You might want to hope that people shared these articles as a joke. I want to hope that. But we can’t: the analysis points to a recent BuzzFeed and Ipsos Public Affairs poll which found that 75 percent of Americans (84 percent of Republicans and 71 percent of Democrats) were easily tricked by fake headlines. What a fantastic year for fact-checking and rational thought and Mark Zuckerberg’s self-awareness.
Helsinki-based developer Remedy Entertainment has blurred the line between Hollywood and games with previous incarnations Max Payne and Alan Wake. Now the studio is combining next-generation visuals with the tension and drama of scripted television. Set in the university town of Riverport, Quantum Break puts players in control of Jack Joyce and Beth Wilder, a pair of ordinary people who are given the extraordinary power to manipulate time after an accident that creates a time rift. Time will randomly break down during the game, which causes disasters in the environment that pause, stutter, rewind and freeze. Fans of Max Payne’s bullet time will see new strategies emerge with gunfights involving time-amplified combat as the player fights against the Monarch Corporation. In addition to the virtual storyline, the game features custom live action storytelling that’s personalized based on the decisions one makes.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Yes. In 2018 President Trump will deliver on some of his protectionist campaign rhetoric by taking punitive actions against China. The most likely triggers for action will be official reports that the Trump administration has commissioned into China’s alleged theft of intellectual property, and its subsidised production of steel and aluminium. The president, spurred on by his trade team, is likely to order retaliatory measures, including tariffs. Whether that marks the first shot in a trade war will depend on how China reacts. A Chinese decision to impose retaliatory tariffs, or to take America to the World Trade Organization, will signal the opening of hostilities.
So what forces will shape the questions asked next year? It depends on who (and where) you are. While buyers should brace for another year of high-stakes bidding wars, residents of the city’s far-flung neighborhoods (I’m talking about you, Grand Concourse) should be ready for an onslaught of prospective residents seeking bargains — bargains, that is, relative to the gilded ZIP codes that are out of the reach of most mortals.
Chinese direct investment in the eurozone was up 37 per cent in 2015, rising to $17.1bn from $12.5bn.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
MasterCard says its index reflects the interconnectedness of major global cities and tracks the ways in which business and leisure jet-setters spend their money.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
A Method to the Madness
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
She then turns back and pecks the man on the cheek, as the crowd erupts in cheers around them.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
‘Faultless performance, you are stunning and you could win this competition,’ Amanda said.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
9.Carol and Susan's Wedding in Friends
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
After China hawk Steve Bannon’s exit there was a temptation to proclaim the death of the Trump White House’s economic nationalism. But that ignored the presence of Donald Trump, who is instinctually a protectionist. He wants “tariffs” rather than deals when it comes to China, as we’ve learned in recent days. He also sees cracking down on China as key to keeping his “America First” promise to his base.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Those with 3-years of driving experience and no records of traffic accident crimes, dangerous driving, drugs or drink driving will be allowed to take examinations for online-driving services.
“Even if you have made your peace with a Fed rate rise there are other reasons to be nervous,” said David Hauner, head of emerging markets at Bank of America Merrill Lynch, who points to falling oil prices and the slowdown in China to illustrate why market volatility measured by the CBOE’s Vix index, a barometer of investor sentiment, has been elevated since August.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The world’s 100 biggest brands still command a significant premium over others and that value increased by 3 per cent to $3.4tn this year, according to the latest BrandZ rankings compiled by Millward Brown, the research agency.
The Disaster Artist is part buddy movie, part show-business fable, and part behind-the-scenes DVD featurette.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Meanwhile, a salesman from online travel company Tuniu Corp told the Financial Times that it had on Friday “removed all tours to South Korea due to the Thaad issue”. A search for South Korean tours on the website returns the message: “Sorry, we have not found a relevant product.”
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
The capital plans to move most of its municipal departments to the suburban district of Tongzhou in 2017, the Beijing Municipal Committee announced on Wednesday.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Walker places sixth thanks to Fast & Furious 6, the biggest hit of his career. He had finished shooting much of Fast & Furious 7 before the tragic car accident that took his life. Word is Universal won’t reshoot the film and will work around the actor’s death.
7.You Haven't Gotten a Raise in the Last Two Years
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The excitement was triggered by a Reuters story that cited documents about the potential transaction as the source of its information. Samsung actually has made at least one play for BlackBerry BBRY -19.77% before, in 2012. As to this latest rumor, the alleged takeover target was the first to refute that a deal is in the works.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Prices at China's factory gates fell for a 34th consecutive month in December, pushed down by falling energy and commodity prices.
Talk show host and comedian Ellen DeGeneres will host the Oscars ceremony for a second time.
6. You dressed 10 times nicer than usual yesterday。
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Brazil's President Dilma Rousseff, who is facing impeachment, slashed her own salary by 10% to $103,400 a year last October as part of a wider austerity drive.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Charles River Ventures合伙人拉斐尔o科拉莱斯认为，学术界、基础设施以及政策等诸多领域的发展，表明2014年是迄今对比特币而言最重要的一年，尽管在此期间比特币波动很大。科拉莱斯表示：“短期而言，那些不懂或不相信比特币大有可为的人很容易攻击这一点。他们批评这一点再容易不过了。在过渡阶段，肯定会有剧烈震荡，所以只看一年的价值波动是愚蠢的。”对于偶尔出现的黑客袭击，科拉莱斯补充道：“短期内肯定会有颠簸，但问题很快就会迎刃而解。而且有一个庞大团体正致力于解决这些问题。因此，尽管存在小的颠簸，你应当对此感到兴奋不已。”
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Temperatures had already risen by 0.8C since the industrial revolution and although last year’s 1C rise may not be repeated every year from now on, scientists said 2016 could turn out to be another exceptionally warm year as the El event continues.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
In this case, the Lakers got a reasonable return for their top trade piece, prepared to give their young players like D'Angelo Russell and Brandon Ingram greater responsibilities down the stretch, and hunkered down for a tank that just might land UCLA star Lonzo Ball.
The ranking is in part based on how successful alumni have been in their careers, as reflected in the salary data.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The companies that have tried — and so far failed — to create a sustained ETF boom in Asia say the need for wholesale reform suggests the market will be defined by a protracted effort to convince both the regulators and customers to redraw the scenery.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
The U.S. Congress and the media will go berserk when Goldman announces the size of its 2009 bonus pool. But the outrage will be brief and of little lasting consequence. The 'hate Goldman Sachs' story has been running just too long.
The Caixin-sponsored series is based on a much smaller sample of private companies than the official PMI reading, which focuses on larger state enterprises, and tends to be more volatile.
A facile assay for rapid detection of COVID-19 antibodies
You turn back the passage and want to find the Page 12, and then you smile.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Every point we think we've reached where James cannot be better than he has been, he then blows past it like a poor center switched onto him. What will be discussed most is his all-encompassing skill, but this is also a testament to the work that James puts in. You can mock all those Instagram videos he puts up, but those are the real reason he's still able to do this; James has never cheated the game, not a day in his life, and the result is incomparable performance night in and night out.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Common areas include two living rooms, both with walls of glass opening to a patio and an in-ground pool. Ceilings rise as high as 28 feet; doors throughout are Spanish cedar. Among the stainless-steel kitchen appliances are a Fisher & Paykel range and two Sub-Zero refrigerators, as well as steel cabinets and sinks. A breakfast bar separates the kitchen from the dining area, which also opens to the patio and pool.
Welcome as they were, surging sales weren't the biggest news of the year. Detroit celebrated when General Motors (GM, Fortune 500) made Mary Barra the auto industry's first female CEO, then held its breath while Ford (F, Fortune 500) CEO Alan Mulally dithered over a move to Seattle and Microsoft. The old Big Three, complaining about straining available production capacity, made plans to expand and hire. Tesla(TSLA) fired up electric car sales and refused to play by industry's rules, while Google(GOOG, Fortune 500) pioneered a car that drives itself.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The Female Warlord Who Had C.I.A. Connections and Opium Routes
戈尔迪·霍恩（Goldie Hawn）曾因影片《仙人掌花》（Cactus Flower）获最佳女配角奖，她的奖杯坐落在一个非常富有禅宗气息的地方——她的“印度房间”，她常在这里冥想。她的小金人并不是唯一一个和主人有共鸣的奖杯，罗素-克洛（Russell Crowe）曾在影片《角斗士》（Gladiator）中身着罗马战士裙装，扮演了一个威猛、极具感情和个性的古罗马战士--司令官马克西姆斯，他的奖杯放在鸡舍中，因为克洛相信小金人能够保佑母鸡下出更大的鸡蛋。
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
While the debate was supposed to be solely about foreign policy, domestic concerns were never far from the surface and the candidates took every opportunity to pivot to their stump speech attacks over the economy and tax. The same was true in the spin room afterwards where both campaign teams dispensed quickly with debate comments and moved instead to analysis of the state of the race in swing states.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Good health, good luck and much happiness throughout the year.
Anti-HIV drug repurposing against SARS-CoV-2
Learn to tweet. Your boss expects it
新美国基金会(New America Foundation)高级研究员李?德鲁特曼(Lee Drutman)在一份给Vox的分析文章中指出，在阿肯色州、北卡罗莱纳州和田纳西州，移民人口是1990年的三倍以上。围绕这些变化产生的焦虑或许可以解释共和党为什么在这个阶段更关注限制移民问题，还有这些州的白人投票者们何以压倒性地支持特朗普。
Length-scale dependence of protein hydration-shell density
Beyoncé featuring Nicki Minaj “Flawless (Remix)” (Parkwood/Columbia)
The programme has enabled me to take a quantum leap in my career and prepared me to take on a strategic C-level [chief-level] role right after graduation, said another alumnus.
The future is always bright if you are an entrepreneur, and the opportunities to create new ventures based on the digitisation of age-old services has a long way to run.
States are falling all over themselves to be chosen as the site for Tesla’s proposed $5 billion Gigafactoryto produce lithium ion batteries. California is competing with Nevada, Arizona, New Mexico, and Texas, and the bidding for the factory, which could employ up to 6,500 people, is said to be up to $500 million.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
About this collection
The requirements come from one of two newly issued regulations over the taxi and online ride-hailing services by China's transportation authority. The regulations will take effect in October and November respectively.
9月，苹果iPhone 6s和6s Plus发售，在中国创下销售记录。中国占苹果公司总营收的逾四分之一。在这里，苹果的产品往往被视为地位的象征，它的竞争对手不仅有来自韩国的劲敌三星(Samsung)，还有日益流行的中国智能手机品牌华为和小米。